
Arylsulfonamide 64B
CAS No. 1342890-83-8
Arylsulfonamide 64B ( HIF inhibitor 64B )
产品货号. M11374 CAS No. 1342890-83-8
Arylsulfonamide 64B(HIF 抑制剂 64B)是一种小分子 HIF 通路抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Arylsulfonamide 64B
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Arylsulfonamide 64B(HIF 抑制剂 64B)是一种小分子 HIF 通路抑制剂。
-
产品描述Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule HIF pathway inhibitor, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration; blocks HIF-1α association with co-factors p300 and CBP at low micromolar concentrations, disrupts the HIF transcription complex by interfering with HIF-1α recruitment of p300/CBP co-factors on hypoxia-responsive elements on target genes; demonstrates strong anti-cancer activity in syngeneic and xenogeneic orthotopic UM mouse models, Arylsulfonamide 64B (64B) is a potent inhibitor of the hypoxiainduced CXCR4 and c-Met-mediated signaling axis that controls in vitro tumor cell motility; shows potent anti-tumor activity at the primary melanoma growth site in the eye, reduces circulating tumor cells, and strongly inhibits spontaneous formation and expansion of metastases in the liver with minimal toxicity.
-
体外实验——
-
体内实验——
-
同义词HIF inhibitor 64B
-
通路Angiogenesis
-
靶点HIF/HIF Prolyl-hydroxylase
-
受体HIF/HIF Prolyl-hydroxylase
-
研究领域——
-
适应症——
化学信息
-
CAS Number1342890-83-8
-
分子量444.546
-
分子式C23H28N2O5S
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCC1(C=CC2=C(O1)C=CC(=N2)CN(C3CCC3)S(=O)(=O)C4=CC(=C(C=C4)OC)OC)C
-
化学全称N-cyclobutyl-N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Van Meir EG, et al. Clin Cancer Res. 2018 Dec 18. pii: clincanres.1368.2018. doi: 10.1158/1078-0432.CCR-18-1368.
产品手册




关联产品
-
HIF-2α agonist 2
HIF-2α agonist 2 (compound 10) 是一种 HIF-2α 激动剂,在 20 μM 剂量下,EC50 值为 1.68 μM。HIF-2α agonist 2 对 786-O-HRE-Luc 细胞无细胞毒性。HIF-2α agonist 2 可用于氧代谢研究。
-
Desidustat
Desidustat 是 HIF 羟化酶的抑制剂。
-
PT-2399
PT-2399 (PT 2399, PT2399) 是一种选择性、有效的 HIF-2α 拮抗剂,可直接与 HIF2α PAS B 结构域结合。